槲皮素可通过自噬减轻高糖诱导的许旺细胞损伤

摘要 : 中国医学科学院北京协和医院的屈岭博士所在课题组在新研究中发现，槲皮素能通过自噬途径减轻高糖对许旺细胞的损害。相关文章发表于2014年6月第12期的《中国神经再生研究(英文版)》杂志上。

高糖导致许旺细胞醛糖还原酶活力和多元醇代谢能力升高，从而导致细胞器损害。自噬可以清除损害的细胞器，提供细胞存活的物质基础。最近研究表明，槲皮素可拮抗高糖抑制的神经细胞增殖。但其是否对许旺细胞有保护作用?该神经保护作用又是否通过自噬途径实现?

来自中国医学科学院北京协和医院的屈岭博士所在课题组研究结果显示，高糖环境下可见，2种大鼠许旺细胞永生化大鼠RSC96细胞和原代培养大鼠许旺细胞自噬小体明显减少，增殖活力和自噬分子标志物Beclin1和 LC3表达明显下降。

而经槲皮素干预后，2种大鼠许旺细胞自噬能力和增殖活力提高，研究结果说明槲皮素能通过自噬途径减轻高糖对许旺细胞的损害。显示结果的文章发表在《中国神经再生研究(英文版)》杂志2014年6月第12期。

原文摘要：

Quercetin alleviates high glucose-induced Schwann cell damage by autophagy

Ling Qu, Xiaochun Liang, Bei Gu, Wei Liu

Quercetin can reverse high glucose-induced inhibition of neural cell proliferation, and therefore may have a neuroprotective effect in diabetic peripheral neuropathy. It is difficult to obtain primary Schwann cells and RSC96 cells could replace primary Schwann cells in studies of the role of autophagy in the mechanism underlying diabetic peripheral neuropathy. Here, we show that under high glucose conditions, there are fewer autophagosomes in immortalized rat RSC96 cells and primary rat Schwann cells than under control conditions, the proliferative activity of both cell types is significantly impaired, and the expression of Beclin-1 and LC3, the molecular markers for autophagy, is significantly lower. After intervention with quercetin, the autophagic and proliferative activity of both cell types is rescued. These results suggest that quercetin can alleviate high glucose-induced damage to Schwann cells by autophagy.

作者：eurekalert

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