评价转基因牛肉的亚慢性毒性

重点实验室最近在专业期刊《Food and Chemical Toxicology》杂志上发表一篇题为“Safety assessment of meat from transgenic cattle by 90-day feeding study in rats”的学术论文。

近几十年来随着转基因技术的不断成熟和发展，其应用范围也越来越广泛。在植物和微生物方面的成功应用开启了农业和生物制药领域的新时代，而在转基因动物的研究上中国后来居上走在了国际前沿，目前已经在实验室成功培育了奶牛、猪、羊等多种高品质转基因动物。

本研究以中国农业大学开发的高效表达转人乳铁蛋白的转基因克隆牛的牛肉为研究对象，通过大鼠90天喂养试验对其安全性进行初步评价。研究中将传统对照牛肉和转基因牛肉分别制成冻干粉并分析其主要营养成分，将冻干粉分别按5%和10%的掺入比例配制饲料，调节其他组分的含量使饲料达到营养均衡。试验期间每日观察动物体征，每周记录动物体重和进食量，实验结束时对动物进行尿液检查、血液细胞学和血液生化学分析，对重要脏器进行称重并进行组织病理学检查。结果表明，进食含有转基因牛肉饲料的大鼠体重、进食量、尿液、血液细胞学和血生化、脏器重量及组织病理学均未产生明显改变。本研究结果提示转基因牛肉的食用安全性与普通牛肉无差别。

目前关于克隆动物的食用安全性多有报道，而对转基因动物的食用安全性方面的研究则几乎未见报道。本研究为转基因动物的食用安全性评价积累了资料，也为我国转基因动物产业化发展的推动提供了技术支撑。

生物谷推荐的英文摘要

Food and Chemical Toxicologydoi.org/10.1016/j.fct.2013.04.003

Safety assessment of meat from transgenic cattle by 90-day feeding study in rats

Shan Liua， Chen-Xi Lia， Xiao-Lian Fenga， Hui-Ling Wanga， Hai-Bo Liua， Yuan Zhia， Gui-Ying Genga， Jie Zhaob， Hai-Bin Xua

The study was carried out to evaluate the subchronic toxicity of meat derived from human lactoferrin gene-modified cattle in male and female Wistar rats. Rats were fed 5% or 10% transgenic meat diet， 5% or 10% conventional meat diet， or AIN93G diet for 90 days. During the study， body weight and food consumption were weighed weekly and clinical observations were conducted daily. At the end of the study， urinary examination， hematology and blood biochemistry examination， macroscopic and microscopic examinations were performed. There were no biologically significant differences in these factors between the rat groups fed transgenic meat diet and conventional meat diet. Therefore， the present 90-day rodent feeding study suggests that meat derived from the transgenic cattle is equivalent to meat from conventional cattle in use as dietary supplements.

文章来源：BIOONNEWS